Dr Nicolas Barry

Nicolas received a Master of Science in Molecular Chemistry from the Université de Rennes and a Master of Science in Chemical Engineering from the Ecole Nationale Supérieure de Chimie de Rennes, France, in 2008. In March 2011, he obtained his PhD in Chemistry under the supervision of Professors Süss-Fink and Therrien at the Université de Neuchâtel, Switzerland. He then moved in October 2011 to the University of Warwick as a Swiss National Science Foundation Postdoctoral Fellow in the group of Professor Peter J. Sadler FRS for two years. In 2014, he started his independent career as a Leverhulme Early Career fellow at the University of Warwick.

In 2016, Nicolas took up a Royal Society University Research Fellowship and a proleptic Lecturer position at the University of Bradford in the School of Chemistry and Biosciences. In 2018, Nicolas was promoted to a proleptic Senior Lecturership at Bradford. His research explores the applications of metallated compounds and nanoparticles in medicine and in materials science.

Academic awards

2018: Fellow of The Higher Education Academy

2018: Academy of Medical Sciences Springboard Award

2016: Royal Society University Research Fellowship

2015: Chartered Chemist; Chartered Scientist

2014: Leverhulme Early Career fellowship

2012: Swiss National Science Foundation, Advanced Fellowship

2011: Swiss National Science Foundation, Early Fellowship

2010: Syngenta Monthey Price
Publications

53. Effect of Temperature on the Nucleation and Growth of Precious Metal Nanocrystals, A. Pitto-Barry and N. P. E. Barry,  Angewandte Chemie International Edition, 2019, 53, DOI: 10.1002/anie.201912219.

52. Anticancer activity of electron‐deficient metal complexes against colorectal cancer in vitro models
M. Azmanova, J. J. Soldevila-Barreda, H. Bani Hani, R. M. Lord, A. Pitto-Barry, S. Picksley, and N. P. E. Barry*, ChemMedChem, 2019, DOI: 10.1002/cmdc.201900528

51. Influence of boron doping on the dynamics of formation of Os metal nanoclusters on graphitic surfaces
A. Pitto-Barry and N. P. E. Barry*Chemical Communications, 2019, 55, 6038-6041.

50. Controlled Release of Carbon Monoxide from a Pseudo Electron-Deficient Organometallic Complex
A. Pitto-Barry and N. P. E. Barry*, ACS Omega, 2018, 3, 15623-15627.

49. In Vivo Selectivity and Localization of Reactive Oxygen Species (ROS) Induction by Osmium Anticancer Complexes That Circumvent Platinum Resistance
J. P. C. Coverdale, H. E. Bridgewater, J.-I. Song, N. A. Smith, N. P. E. Barry, I. Bagley, P. J. Sadler, and I. Romero-Canelon, Journal of Medicinal Chemistry, 2018, 61, 9246-9255.

48. New Class of Hybrid Materials for Detection, Capture, and “On-Demand” Release of Carbon Monoxide
A. Pitto-Barry, A. Lupan, C. Ellingford, A. A. A. Attia, and N. P. E. Barry*, ACS Applied Materials and Interfaces, 2018, 10, 13693-13701.

47. Schizophrenia: synthetic strategies and recent advances in drug design
M. Azmanova, A. Pitto-Barry*, and N. P. E. Barry*, Medicinal Chemistry Communications, 2018, 9, 759-782.

46. Anti-inflammatory activity of electron-deficient organometallics
J. Zhang, A. Pitto-Barry, L. Shang*, and N. P. E. Barry*, Royal Society Open Science, 2017, 4, 170786.

45. Halide Control of N,N-Coordination versus N,C-Cyclometalation and Stereospecific Phenyl Ring Deuteration of Osmium(II) p-Cymene Phenylazobenzothiazole Complexes
R. J. Needham, A. Habtemariam, N. P. E. Barry, G. Clarkson, and P. J. Sadler*, Organometallics, 2017, 36, 4367-4375.

44. Controlled fabrication of osmium nanocrystals by electron, laser and microwave irradiation and characterisation by microfocus X-ray absorption spectroscopy
A. Pitto-Barry, K. Geraki, M. D. Horbury, V. G. Stavros, J. F. W. Mosselmans, R. I. Walton, P. J. Sadler*, and N. P. E. Barry*, Chemical Communications, 2017, 53, 12898-12901.

43. Pseudo electron-deficient organometallics: limited reactivity towards electron-donating ligands
A. Pitto-Barry, A. Lupan, M. Zegke, T. Swift, A. A. A. Attia, R. M. Lord, and N. P. E. Barry*, Dalton Transactions201746, 15676-15683.

42. Pyrene: The Guest of Honor
N. P. E. Barry*, B. Therrien*, in Organic Nanoreactors, Samahe Sadjadi, Oxford: Elsevier, 2016, 421-461.

41. Nanoparticles of chitosan conjugated to organo-ruthenium complexes
Y. Wang, A. Pitto-Barry, A. Habtemariam, I. Romero-Canelon, P J. Sadler*, N. P. E. Barry*, Inorganic Chemistry Frontiers, 2016, 3, 1058-1064.

40. Dynamics of formation of Ru, Os, Ir and Au metal nanocrystals on doped graphitic surfaces
A. Pitto-Barry, P. J. Sadler, N. P. E. Barry*, Chemical Communications, 2016, 52, 3895-3898.

39. The synthesis and unexpected solution chemistry of thermochromic carborane-containing osmium half-sandwich complexes
A. Pitto-Barry, A. South, A. Rodger, N. P. E. Barry*, Dalton Transactions, 2016, 45, 1763-1768.

38. Synthesis and controlled growth of osmium nanoparticles by electron irradiation
A. Pitto-Barry, L. M. A. Perdigao, M. Walker, J. Lawrence, G. Costantini*, P. J. Sadler*, N. P. E. Barry*, Dalton Transactions, 2015, 44, 20308-20311, part of Dalton Transactions’ HOT articles from 2015.

37. Osmium Atoms and Os2 Molecules Move Faster on Selenium-Doped Compared to Sulfur-Doped Boronic Graphenic Surfaces
N. P. E. Barry*, A. Pitto-Barry, J. Tran, S. E. F. Spencer, A. M. Johansen, A. M. Sanchez, A. P. Dove, R. K. O’Reilly, R. J. Deeth, R. Beanland, P. J. Sadler*, Chemistry of Materials, 2015, 27, 5100-5105.

36. Arene ruthenium dithiolato–carborane complexes for boron neutron capture therapy (BNCT)
I. Romero-Canelón, B. Phoenix, A. Pitto-Barry, J. Tran, J. J. Soldevila-Barreda, N. Kirby, S. Green*, P. J. Sadler*, N. P. E. Barry*, Journal of Organometallic Chemistry, 2015, 796, 17-25, dedicated to Professor Georg Süss-Fink on the occasion of his 65th birthday.

35. Designing Supramolecular Liquid-Crystalline Hybrids from Pyrenyl-Containing Dendrimers and Arene Ruthenium Metalla-Cycles
A. Pitto-Barry, N. P. E. Barry, V. Russo, B. Heinrich, B. Donnio*, B. Therrien*, and R. Deschenaux*, Journal of the American Chemical Society, 2014, 136, 17616-17625.

34. Precious metal carborane polymer nanoparticles: characterisation of micellar formulations and anticancer activity
N. P. E. Barry*, A. Pitto-Barry, I. Romero-Canelón, J. Tran, J. J. Soldevila-Barreda, I. Hands-Portman, C. J. Smith, N. Kirby, A. P. Dove, R. K. O’Reilly, and P. J. Sadler*, Faraday Discussions, 2014, 175, 229-240.

33. Fabrication of crystals from single metal atoms
N. P. E. Barry*, A. Pitto-Barry, A. M. Sanchez, A. P. Dove, R. J. Procter, J. J. Soldevila-Barreda, N. Kirby, I. Hands-Portman, C. J. Smith, R. K. O’Reilly, R. Beanland*, and P. J. Sadler*, Nature Communications, 2014, 5, 3851.

32. Pluronic® block-copolymers in medicine: From chemical and biological versatility to rationalisation and clinical advances
A. Pitto-Barry*, N. P. E. Barry*, Polymer Chemistry, 2014, 5, 3291-3297.

31. 100 years of metal coordination chemistry: from Alfred Werner to anticancer metallodrugs
N. P. E. Barry and P. J. Sadler*, Pure and Applied Chemistry, 2014, 86, 1897-1910.

30.The Potent Oxidant Anticancer Activity of Organoiridium Catalysts
Z. Liu, I. Romero-Canelón, B. Qamar, J. M. Hearn, A. Habtemariam, N. P. E. Barry, A. M. Pizarro, G. J. Clarkson, P. J. Sadler*, Angewandte Chemie International Edition, 2014, 53, 3941–3946.

29. A multinuclear 1H, 13C and 11B solid-state MAS NMR study of 16- and 18-electron organometallic ruthenium and osmium carborane complexes
N. P. E. Barry, T. F. Kemp, P. J. Sadler*, J. V. Hanna*, Dalton Transactions, 2014, 43, 4945-4949, part of a themed issue on Carboranes.

28. Rational design of an arene ruthenium chlorin conjugate for in vivo anticancer activity
M. Pernot, N. P. E. Barry, T. Bastogne, C. Frochot, M. Barberi-Heyob*, B. Therrien*, Inorganica Chimica Acta, 2014, 414, 134-140.

27. Challenges for Metals in Medicine: How Nanotechnology May Help to Shape the Future
N. P. E. Barry*, P. J. Sadler*, ACS Nano, 2013, 7, 5654-5659.

26. Exploration of the medical periodic table: towards new targets
N. P. E. Barry, P. J. Sadler*, Chemical Communications, 2013, 49, 5106-5131.

25. Thermochromic organometallic complexes: experimental and theoretical studies of 16- to 18-electron interconversions of adducts of arene Ru(II) carboranes with aromatic amine ligands
N. P. E. Barry, R. J. Deeth, G. J. Clarkson, I. Prokes, P. J. Sadler*, Dalton Transactions, 2013, 42, 2580-2587.

24. Metal-DNA Coordination Complexes
A. M. Pizarro, N. P. E. Barry, P. J. Sadler*, in Comprehensive Inorganic Chemistry II, Vol 3, Jan Reedijk and Kenneth Poeppelmeier, editors. Oxford: Elsevier; 2013, 752-784.

23. Systems biology approach for in vivo photodynamic therapy optimization of ruthenium-porphyrin compounds
M. Pernot, T. Bastogne, N. P. E. Barry, B. Therrien, G. Koellensperger, S. Hann, V. Reshetov, M. Barberi-Heyob*, Journal of Photochemistry and Photobiology B Biology, 2012, 117, 80-89.

22. Dicarba-closo-dodecarborane-containing half-sandwich complexes of ruthenium, osmium, rhodium and iridium: biological relevance and synthetic strategies
N. P. E. Barry, P. J. Sadler*, Chemical Society Reviews, 2012, 41, 3264-3279.

21. Delivery of Floxuridine Derivatives to Cancer Cells by Water-Soluble Organometallic Cages
J. W. Yi, N. P. E. Barry, M. A. Furrer, O. Zava, P. J. Dyson, B. Therrien*, B. H. Kim*, Bioconjugate Chemistry, 2012, 23, 461-471.

20. Organometallic Cages as Vehicles for Intracellular Release of Photosensitizers
F. Schmitt, J. Freudenreich, N. P. E. Barry, L. Juillerat-Jeanneret, G. Süss-Fink, B. Therrien*, Journal of the American Chemical Society, 2012, 134, 754-757.

19. Encapsulation of hydrophobic pyrenyl-cycloplatinate complexes within a water-soluble arene ruthenium metalla-cage
N. P. E. Barry, O. Zava, W. Wu, J. Zhaoc, B. Therrien*, Inorganic Chemistry Communications, 2012, 18, 25-28.

18. Encapsulation of inorganic and organic guest molecules into an organometallic hexacationic arene osmium metalla-prism: Synthesis, characterisation and anticancer activity
N. P. E. Barry, O. Zava, P. J. Dyson, B. Therrien*, Journal of Organometallic Chemistry, 2012, 705, 1-6.

17. Efficient photodynamic therapy of cancer using chemotherapeutic porphyrin–ruthenium metalla-cubes
F. Schmitt, N. P. E. Barry, L. Juillerat-Jeanneret, B. Therrien*, Bioorganic and Medicinal Chemistry Letters, 2012, 22, 178-180.

16. Excellent Correlation between Drug Release and Portal Size in Metalla-Cage Drug-Delivery Systems
N. P. E. Barry, O. Zava, P. J. Dyson*, B. Therrien*, Chemistry A European Journal, 2011, 17, 9669-9677.

15. Anticancer activity of tetra-cationic arene ruthenium metalla-cycles
N. P. E. Barry, F. Edafe, B. Therrien*, Dalton Transactions, 2011, 40, 7172-7180.

14. Encapsulation of pyrene-functionalised poly(benzyl ether) dendrons into an arene ruthenium metalla-prism
A. Pitto-Barry, N. P. E. Barry, O. Zava, R. Deschenaux, B. Therrien*, Chemistry An Asian Journal, 2011, 6, 1595-1603.

13. Double Targeting of Tumours with Pyrenyl-Modified Dendrimers Encapsulated in an Arene-Ruthenium Metalla-Prism, A. Pitto-Barry, N. P. E. Barry, O. Zava, R. Deschenaux, P. J. Dyson, B. Therrien*, Chemistry A European Journal, 2011, 17, 1966-1971.

12. Ru2(CO)4(OOCR)2L2 sawhorse-type complexes containing axial 5-(4-pyridyl)-10,15,20-triphenylporphyrin ligands
M. Gras, N. P. E. Barry, B. Therrien, G. Süss-Fink*, Inorganica Chimica Acta, 2011, 371, 59-62.

11. Synthesis, Characterisation and Anticancer Activity of Porphyrin Containing Organometallic Cubes
N. P. E. Barry, O. Zava, P. J. Dyson, B. Therrien*, Australian Journal of Chemistry, 2010, 63, 1529-1537.

10. In- and out-of-cavity interactions by modulating the size of ruthenium metalla-rectangles
N. P. E. Barry, J. Furrer, B. Therrien*, Helvetica Chimica Acta, 2010, 93, 1313-1328.

9. Anticancer activity of opened arene ruthenium metalla-assemblies
N. P. E. Barry, O. Zava, J. Furrer, P. J. Dyson, B. Therrien*, Dalton Transactions, 2010, 39, 5272-5277.

8. Permanent encapsulation or host-guest behavior of aromatic molecules in hexanuclear arene ruthenium prisms
J. Freudenreich, N. P. E. Barry, G. Süss-Fink, B. Therrien*, European Journal of Inorganic Chemistry, 2010, 2400-2405.

7. Anticancer activity of osmium metalla-rectangles
N. P. E. Barry, F. Edafe, P. J. Dyson, B. Therrien*, Dalton Transactions, 2010, 39, 2816-2820.

6. Designing the host-guest properties of tetranuclear arene ruthenium metalla-rectangles to accommodate a pyrene molecule,
N. P. E. Barry, J. Furrer, J. Freudenreich, G. Süss-Fink, B. Therrien*, European Journal of Inorganic Chemistry, 2010, 725-728.

5. Interactions of ruthenium coordination cubes with DNA,
N. P. E. Barry, N. H. Abd Karim, R. Vilar*, B. Therrien*, Dalton Transactions, 2009, 10717-10719.

4. Host-guest chemistry in the hexanuclear arene ruthenium metalla-prismatic cage [Ru6(p-cymene)6(tpt)2(dhnq)3]6+,
N. P. E. Barry, B. Therrien*, European Journal of Inorganic Chemistry, 2009, 4695-4700.

3. Highly efficient NMR enantiodiscrimination of chiral octanuclear metalla-boxes in polar solvent
N. P. E. Barry, M. Austeri, J. Lacour*, B. Therrien*, Organometallics, 2009, 28, 4894-4897.

2. Photochemical [2 + 2] cycloaddition of the olefinic double bonds in the supramolecular rectangle [Ru4(p-cymene)4(oxalato)2(4,4′-bipyridylethylene)2]4+
N. P. E. Barry, B. Therrien*, Inorganic Chemistry Communications, 2009, 12, 465-468.

1. Organometallic boxes built from 5,10,15,20-tetra(4-pyridyl)porphyrin panels and hydroxyquinonato-bridged diruthenium clips,
N. P. E. Barry, P. Govindaswamy, J. Furrer, G. Süss-Fink, B. Therrien*, Inorganic Chemistry Communications, 2008, 11, 1300-1303.

Patents

2. A. Pitto-Barry, and N. P. E. Barry, “CO absorber”, 2018, GB1806060.8, PCT/GB2019/051059

1. A. Pitto-Barry, R. Beanland, P. J. Sadler and N. P. E. Barry, “Nanocrystals”, 2015, PCT/GB2015/051264